5 Best peptides for Weight Loss (Injectable + Fat Loss)

And don't just take my word for it, did you know that a study published in the Journal of Endocrinology and Metabolism found that individuals who used peptides for weight loss experienced an average of 14% reduction in body fat???

That's a statistic that'll make you want to throw out those kale chips and hop on the peptide train!?

Now, I know what you're thinking, "Peptides? That sounds like a fancy word for a chemistry experiment." But trust me, it's not as intimidating as it sounds. Peptides are basically little protein building blocks that regulate hormones in our bodies. And while SARMs and steroids can carry some gnarly side effects, peptides are generally safe for human consumption if used correctly.?

So, without further ado, let's dive into the top 5 magical peptides that can aid your weight loss journey and help you finally lose weight and shed those pesky pounds!?

Key Takeaways??

1. The 5 best peptides for weight loss include Semaglutide, AOD 9605, CJC-1295, Tesamorelin, and 5-Amino-1MQ.?
2. These peptides generally work by either increasing growth hormone levels, inducing lipolysis, or inhibiting lipogenesis.??
3. Semaglutide and AOD 9604 are FDA-approved peptides owing to their long-term safety profile and therapeutic benefits.??

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What are Peptides??

Peptides are small chains of amino acids and are considered the building blocks of proteins (1). They're prioritized over long proteins due to their short structure and rapid absorption.??

Compared to previous years, more research and human-based clinical trials are emerging, proving the efficacy and wide array of benefits from both natural and synthetic peptides.??

Most of these peptides are used for muscle building, improved strength and endurance, and weight loss. Peptides are also used for sleep cycle regulation, cardiovascular benefits, and increasing bone density. Peptides also provide anti-inflammatory properties, which can cause rapid wound healing.??

#1 Best Injectable Peptide for Weight Loss: Semaglutide??

The first peptide we are going to talk about is Semaglutide!??

Semaglutide is a receptor agonist of Glucagon-like peptide 1 (GLP-1), a hormone secreted by the intestinal epithelium. This, in turn, assists in the management and control of the glycemic profile of an individual.??

Fig 1. Difference between Semaglutide and GLP-1 agonist on weight loss?

Besides this, Semaglutide also regulates pancreatic hormones, thereby keeping blood sugar levels in check. Peptide decreases the local glucagon levels and reduces the conversion of glucagon to glucose.??

In one of the clinical trials, Semaglutide resulted in a 15% body weight loss. This peptide helps in controlling appetite urges, reducing VLDL levels and triglycerides.??

Semaglutide is an anti-obesity medication indicated in patients with Type II Diabetes mellitus and hypercholesterolemia (2 ). Surprisingly, it is one of the few peptides approved by the FDA due to its potent efficacy.??

It is important to abide by the right amount of peptide dosage. For Semaglutide, 0.25-2.4 mg can be safely consumed. This peptide can be cycled for 6-8 weeks straight.?

Best For:?

• Maintains Euglycemia?
• Suppresses appetite?
• FDA-approved anti-obesity medication (Can be prescribed)?

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#2 Peptide for Weight Loss: AOD 9604?

AOD 9604 is a growth Hormone analog consisting of 15 amino acids (similar to growth hormone) (3 ). AOD 9604 is one of the few potent anti-obesity peptides due to its fat loss attributes.??

Luckily, the mode of action followed by the peptide is quite simple to understand. This peptide targets fat-enriched areas of the body and promotes lipolysis alongside inhibiting lipogenesis (4 ).??

This means your body breaks down excess fat, utilizes it for energy expenditure, and simultaneously inhibits fat synthesis. This results in a net loss of excessive fat from the body!??

Nonetheless, AOD 9604 doesn't cause any dysregulation in blood sugar levels. Like Semaglutide, AOD 9604 is also an FDA-approved drug.??

However, with AOD 9604, you must take care of the correct dosage. It is advised to ingest no more than 0.25 to 1 mg of the Peptide. You can cycle AOD 9604 for 24 weeks for optimum results.??

With this Peptide, you may experience slight uneasy side effects like headache, indigestion, and nausea.??

Best For:?

• Promotes increased fat burning?
• Reduces the chances of hypercholesterolemia?
• FDA-approved (Can be prescribed)?

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#3 Peptide for Weight Loss: CJC 1295 ?

This is a 30 amino acid containing peptide, analogous to growth hormone releasing hormone (5 ). With this, CJC 1295 stimulates the release of growth hormone from the anterior pituitary gland.??

Being a growth hormone releasing hormone analog, this peptide targets adipocytes and raises fat metabolism (6 ). Besides this, it also increases lean muscle mass, better endurance, and regulates the sleep cycle. With its fat metabolism attribute, it can help increase fat burning.??

Stacking CJC 1295 with Ipamorelin is recommended for improved and rapid results. Further, it is suggested to use Drug Affinity Complex (DAC) with CJC 1295 for a greater half-like of 6 to 10 days. You might experience slight side effects like mood swings and increased body temperature while cycling with CJC 1295.??

Regarding the correct dose, it is advised to use 250 to 300 mcg per day. You can cycle CJC 1295 for 60 to 90 days, followed by a one-month off-cycle.???

Best For:?

• Improves lean muscle mass?
• Stimulates fat oxidation?
• May improve sleep cycles?

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#4 Peptide for Weight Loss: Tesamorelin?

Tesamorelin was initially used specifically to treat HIV-associated lipodystrophy. The peptide caused a considerable decrease in visceral adipose tissue after cycling with it. The peptide, like CJC 1295, is a growth hormone releasing hormone analog, and increases the stimulation and natural production of growth hormone from the anterior pituitary gland.??

It targets cells like adipocytes and hepatocytes to increase fat metabolism (7 ). Few clinical trials also indicate low trunk fat, decreased waist circumference, and waist-to-hip ratio. One of the best things about Tesamorelin is its ability to release Growth Hormones within normal homeostatic levels.??

For dosage, it is recommended to use 2 mg of Tesamorelin for effective weight loss therapy. It should, however, be cycled at most 14 weeks for optimum benefits.??

The only side effect of tesamorelin is its ability to cause insulin resistance when used for extended periods. Therefore, going off the cycle is fundamental.??

Best For:?

• HIV-associated lipodystrophy?
• Promotes fat breakdown/metabolism?
• May mitigate the risk of cardiovascular disorders?

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#5 Peptide for Weight Loss: 5-Amino-1MQ?

This is one of the best anti-obesity drugs with a pretty unique mechanism of action. Peptide is a derivative of methyl quinolone. Peptide is seen to work by blocking the effect of Nicotinamide N-methyltransferase(NNMT).??

With NNMT blocking, the local levels of nicotinamide dinucleotide, aka NAD+, increase, leading to a faster and more efficient cellular metabolism (8 ). Due to enhanced energy requirements, your body utilizes excessive fat stores and decreases fat synthesis.??

This means that you can reduce unwanted weight quite efficiently via this mechanism.??

For optimum results, it is recommended to use one capsule per day for 2 to 3 months.??

Best For:?

• Treat metabolic disorders?
• Reverses obesity induced by diet?
• Uses fat cells for energy production?

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How do Peptides for Weight loss Work???

Most of the peptides, if not all, work via a common mechanism of action. They increase the release of Growth Hormone from the anterior pituitary gland, which leads to systemic effects. This is primarily seen in peptides used explicitly for muscle growth and endurance.??

As far as weight loss peptides are concerned, it gets pretty interesting!??

Some of these peptides work by increasing growth hormone levels. The growth hormone, in turn, targets specific sites like adipocytes and hepatocytes, causing raised cellular metabolism and fat burning.??

Besides this, most peptides also work by rapidly increasing the process of lipolysis and simultaneously inhibiting excess lipogenesis from occurring. This leads to a net loss of fat.??

A few peptides also work by regulating hormones responsible for glycemic control, like insulin and glucagon. With more insulin, glucose is transported inside the cells for energy expenditure. This subsequently aids in further weight loss.??

How to use Peptides???

One often prefers oral methods of ingesting peptides as the easiest way, and rightfully so. However, oral peptides provide low bioavailability leading to fewer benefits in return. Therefore, it is advised to use injectable forms of peptides for optimum effects.??

Nonetheless, peptides come in other forms, such as creams, nasal sprays, and transdermal patches.??

However, it is the injectable form that requires the most caution. For this purpose, one needs to reconstitute a lyophilized version of the drug. You can do it by carefully adding drops of bacteriostatic water inside the vial according to the recommended dose.??

Importantly, It is essential to keep the vial in favorable conditions for reuse.??

Are Peptides Legal???

Most of the peptides lack clinical trials involving humans as subjects. Therefore, in the United States, peptides are prohibited for human consumption by the FDA when prescribed by a doctor. However, Semaglutide and AOD 9605, due to their medical advantages, are indeed approved by the institute under prescription.??

Nonetheless, one can always purchase peptides for research purposes.??

Are Peptides Safe???

Most clinical studies involving peptides are done on animal subjects and rarely on humans. However, these trials have yielded promising and indeed very safe results.??

Besides all the minor side effects such as headache, nausea, and abdominal discomfort, peptides are safe for consumption. Nevertheless, make sure you use the proper dosage guidelines to prevent any adverse reactions from occurring.??

FAQs on Peptides??

Can peptides cause side effects??

The majority of the peptides are safe for human consumption. However, mild effects such as headaches, dizziness, or nausea may be reported.???

What peptides are used for weight loss???

For weight loss, one can cycle these five peptides: CJC 1295, AOD 9605, Tesamorelin, Semaglutide, and 5-Amino-1MQ.??

References:??

1. Forbes J, Krishnamurthy K. Biochemistry, Peptide. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 29, 2022.?
2. Bergmann NC, Davies MJ, Lingvay I, Knop FK. Semaglutide for the treatment of overweight and obesity: A review. Diabetes Obes Metab. 2023;25(1):18-35. doi:10.1111/dom.14863?
3. Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D. Detection and in vitro metabolism of AOD9604. Drug Test Anal. 2015;7(1):31-38. doi:10.1002/dta.1715?
4. Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-278. doi:10.1159/000053183?
5. Timms M, Ganio K, Forbes G, Bailey S, Steel R. An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma. Drug Test Anal. 2019;11(6):804-812. doi:10.1002/dta.2554?
6. Van Hout MC, Hearne E. Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions. Subst Use Misuse. 2016;51(1):73-84. doi:10.3109/10826084.2015.1082595?
7. Lake JE, La K, Erlandson KM, et al. Tesamorelin improves fat quality independent of changes in fat quantity. AIDS. 2021;35(9):1395-1402. doi:10.1097/QAD.0000000000002897?
8. Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. doi:10.1016/j.bcp.2017.11.007?

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